Ganglionic blocker

A ganglionic blocker (or ganglioplegic) is a type of medication that inhibits postganglionic transmission,[1] primarily by acting as a nicotinic antagonist.[2]

Because ganglionic blockers block the parasympathetic nervous system and sympathetic nervous system, the effect of these drugs depends upon the dominant tone in the organ system.[3]

Contents

Examples

Examples include hexamethonium, pentolinium, mecamylamine, trimetaphan, and pempidine,nicotine

Others include:[4]

Uses

Ganglionic blockers are used less frequently now than they were in the past, because more selective agents are now available. However, they are still used in some emergency situations, such as aortic dissection.

Side-Effects

References

  1. ^ "Dorlands Medical Dictionary:ganglioplegic". http://www.mercksource.com/pp/us/cns/cns_hl_dorlands_split.jsp?pg=/ppdocs/us/common/dorlands/dorland/four/000043626.htm. 
  2. ^ MeSH Ganglionic+blockers
  3. ^ "PHARMACOLOGY OF GANGLIONIC TRANSMISSION, 1998". Archived from the original on 2008-05-01. http://web.archive.org/web/20080501003627/http://www.med.howard.edu/pharmacology/handouts/autono4.htm. Retrieved 2008-10-04. 
  4. ^ MeSH list of agents 82005730
Types
Classes
see Enzyme inhibition
Other
Miscellaneous
Cofactor (see Enzyme cofactors) • Precursor (see Amino acids)
Sympatholytic (and closely related) antihypertensives (C02)
Sympatholytics
(antagonize α-adrenergic
vasoconstriction)
Central
Adrenergic release inhibitors
Ganglion-blocking/nicotinic antagonist
Peripheral
Indirect
Direct
Non-selective α blocker
Other antagonists
dual (Bosentan) • selective (Ambrisentan, Sitaxentan)

M: VAS

anat(a:h/u/t/a/l,v:h/u/t/a/l)/phys/devp/cell/prot

noco/syva/cong/lyvd/tumr, sysi/epon, injr

proc, drug(C2s+n/3/4/5/7/8/9)